Does the evidence show that prokinetic agents are effective in healing esophagitis and improving symptoms of GERD?
نویسندگان
چکیده
Gastroesophageal reflux disease (GERD) is common in affluent societies, and its prevalence is also on the rise in developing regions such as Southeast Asia.1 When heartburn and regurgitation are the dominant symptoms, a diagnosis of GERD can be made. Manzotti and colleagues report in Open Medicine the findings of a systematic review in which they evaluate the use of prokinetic agents in the treatment of reflux esophagitis.
منابع مشابه
Prokinetic drug utility in the treatment of gastroesophageal reflux esophagitis: a systematic review of randomized controlled trials
BACKGROUND Esophagitis caused by gastroesophageal reflux disease (GERD) results in appreciable morbidity and economic burden. No systematic review has addressed the effectiveness of prokinetic drugs in the treatment of GERD esophagitis in adults. OBJECTIVE To determine the utility of prokinetic drugs in improving symptoms and endoscopic lesions in patients with GERD esophagitis. METHODS We ...
متن کاملPharmacologic modulation of motility.
Etiologically, gastroesophageal reflux disease (GERD) can be regarded as motility disorder: Although blocking acid is effective in the treatment of GERD, it does not overcome the underlying pathologic factors that allow acid, pepsin, and bile to reflux into the esophagus. Prokinetic agents address the upper gastrointestinal motility disturbances contributing to GERD and, thus, have an important...
متن کاملClinical management of infants and children with gastroesophageal reflux disease.
Gastroesophageal reflux refers to the passage of gastric contents including food, acid, and digestive enzymes up into the esophagus. Reflux is most commonly recognized in infants when it is associated with regurgitation, known as "spitting up," and it is usually a self-limited, benign process that has little or no effect on normal weight gain or development. Adults and adolescents may also have...
متن کاملProton pump inhibitors in the management of gastroesophageal reflux disease.
The primary treatment goals in patients with gastroesophageal reflux disease (GERD) are relief of symptoms, prevention of symptom relapse, healing of erosive esophagitis and prevention of complications. The severity of GERD is directly correlated with the degree and duration of oesophageal acid exposure and is highly pH dependent. Healing of reflux esophagitis is directly correlated with the in...
متن کاملCurrent Pharmacological Management of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), a common disorder with troublesome symptoms caused by reflux of gastric contents into the esophagus, has adverse impact on quality of life. A variety of medications have been used in GERD treatment, and acid suppression therapy is the mainstay of treatment for GERD. Although proton pump inhibitor is the most potent acid suppressant and provides good effic...
متن کامل